“Innovative Brain Scanning for Alzheimer’s Disease Screening Unveiled
Clinical Trials with the Neuronetrix’ COGNISION headset at the
University of Kentucky Begin in 2008”

Neuronetrix Partners with the University of Kentucky in an Alzheimer’s Disease Screening Study.

LEXINGTON, KY (Jan. 23, 2008)—Researchers at the University of Kentucky Sanders-Brown Center on
Aging are launching an Alzheimer’s screening clinical trial with Neuronetrix’s innovative brain
scanning system, called COGNISION™. The study will involve brainwave assessments using a
technology called event-related potentials (ERP’s). The study is expected to validate the
performance of the COGNISION™ system and to demonstrate the system’s applicability in a primary
care setting. Up to 100 Alzheimer sufferers and controls will participate over the next 6-12
months.

During the study patients will wear a sophisticated electronic headset which will record brain
activity in response to an auditory stimulus. The process is similar to hearing screening tests
performed on newborn infants throughout the country. The data is then uploaded to an online
database where a powerful pattern recognition engine will correlate the ERP tests with known
brainwave patterns.

The COGNISION™ test is expected to be the first approved Alzheimer’s disease screening test which
directly evaluates a patient’s cognitive performance. “We are not looking at a surrogate biomarker
which may or may not correlate with Alzheimer’s, instead, we are directly measuring the cognitive
deficits caused by the disease.” says K.C. Fadem, co-founder of Neuronetrix.
It is generally believed that the drugs used to treat Alzheimer’s, such as market leader Aricept®
from Pfizer, are most effective early in the disease process. Because of this, a national focus
has been placed on the importance of Alzheimer’s screening to determine optimum treatment paths in
the early stage of the disease. At least one organization of medical experts, the AD Screening
Discussion Group, has advocated that Alzheimer’s disease screenings become a routine part of the
application for Medicare.

Alzheimer’s disease affects about 5 million Americans with 500,000 new cases reported each year.
This number is expected to grow to 16 million by 2050. The CDC recently reported that Alzheimer’s
disease moved up to 7th place from 8th place among the leading causes of death in 2004, passing
influenza and pneumonia.

The Sanders-Brown Center at the University of Kentucky is one of only 32 Alzheimer’s Centers of
Excellence in the country. Neuronetrix is planning a follow on study to evaluate the COGNISION™
System on a commercial scale that will be performed at other Alzheimer’s Centers of Excellence
including the University of Pennsylvania and Indiana University.

For more information, go to www.neuronetrix.com.

Dawn Marie Yankeelov, ASPectx
PR Consultant
502-292-2351
dawny@aspectx.com

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